Dermal & Melanocortin Research
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Specifically, the biosynthesis of amino acids (37 KOs), was significantly down-represented, including cysteine and methionine metabolism ( metA , metB , metK , mtnN , thrB , cysK , patB and L-serine dehydratase ), the biosynthesis of lysine ( dapA , dapB , dapE , dapH , dapL , argD , patA and lysA ), the metabolism of histidine ( hisA , hisB , hisE , hisH and hisI ), glycine, serine and threonine ( glyA , thrB , thrC and L-serine dehydratase ), alanine, aspartate and glutamate (asnA, asnB and argH), the biosynthesis of phenylalanine, tyrosine and tryptophan ( aroD and aroE ) and the biosynthesis of arginine ( argD and argH )
The neuropathological changes of AD brain, based on brain imaging studies, show slow and progressive cerebral atrophy, where the frontal and temporal cortices often have enlarged sulcal spaces with atrophy of the gyri, while primary motor and somatosensory cortices most often appear unaffected (Perl, 2010)
